[staff-physics-and-astronomy-HL-UHD-UD] Colloquium Senior Speaker t.b.c. and Sylvia Spies

[Beta NAT Secretariaat]

Programme
Location: Vrije Universiteit, VO Research Building, Spectrum 5
Walk-in Pizza: 12:15 - 12:30
Start colloquium: 12:30

12:30 - 12:50 Sylvia Spies, PhD candidate, Biophotonics & Medical Imaging, VU Amsterdam
Titel: Rapid Assessment of Biopsies using Higher Harmonic Generation Microscopy
Abstract: Histopathology is the gold standard for cancer diagnosis. However, this technique is time-consuming and labor-intensive and cannot provide rapid feedback during clinical procedures. A rapid assessment of biopsies could help in decision making during biopsy procedures (or surgeries) and could create opportunity for a 'one-stop-shop', where diagnosis and treatment are combined into one procedure.
Higher harmonic generation (HHG) microscopy combines third harmonic generation (THG), second harmonic generation (SHG) and two- and three-photon excited autofluorescence (2PEF and 3PEF) to visualize cells, collagen, elastin and other fluorescent molecules, without any preparation or staining. Imaging is achieved within 1-3 seconds per field of view (400x400 μm), allowing a biopsy to be scanned in a few minutes.
We are performing multiple studies at the Amsterdam UMC, mainly on lung cancer, but also some other organs. HHG-imaging reveals histology-like architectural features and cellular details, while also providing complementary information such as clear differentiation between collagen and elastin. In addition, we are working on AI models to automatically analyze the images. Therefore, HHG has promising clinical applications and may even create opportunity for the ‘one-stop-shop’.
12:50 -13:45 Senior Speaker t.b.c.
Title:  cc
Abstract: cc


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