[Onwar-phd] FW: Tuesday 14 April 16.00 - 17.00 room D1.111, Science Park 904, 1098 XH Amsterdam ABC & SILS Center for Neuroscience - Seminar By Dr. Matthijs oude Lohuis

[Hubregtse, K. (Kim)]

FYI!

Kim Hubregtse
PhD Coordinator, Center for Neurogenomics and Cognitive Research (CNCR) | cncr.nl<https://urldefense.proofpoint.com/v2/url?u=http-3A__www.fga.cncr.nl_&d=DwMGaQ&c=euGZstcaTDllvimEN8b7jXrwqOf-v5A_CdpgnVfiiMM&r=9OwVS9X1FxVRZt8kWeXGFQ&m=-x3i2BCg8s4pBUcB2KYY_SpPEm8PaDLe7duFCHZCuYw&s=b-wMtP4X2ETFG4ZicQd-um8A3-gQc2MTW3iGEPWkgjE&e=>
Coordinator Graduate School Neurosciences Amsterdam Rotterdam (ONWAR) | onwar.nl<https://urldefense.proofpoint.com/v2/url?u=http-3A__www.onwar.nl_&d=DwMGaQ&c=euGZstcaTDllvimEN8b7jXrwqOf-v5A_CdpgnVfiiMM&r=9OwVS9X1FxVRZt8kWeXGFQ&m=-x3i2BCg8s4pBUcB2KYY_SpPEm8PaDLe7duFCHZCuYw&s=d_7gS0pVlzuH00hbTRS8R3N7UxlmHoSWkzxF3C3rFZA&e=>
Working days: Mo, Tu, We, Th, Fr | k.hubregtse at vu.nl<mailto:k.hubregtse at vu.nl> | T: +31 205980955
Mailing address: De Boelelaan 1100, 1081 HZ Amsterdam
Visiting address: VUO 8B-145 | E-mail disclaimer<https://vu.nl/en/about-vu/more-about/about-the-vu-website> | www.vu.nl<https://vu.nl/en/>


Van: Aly Eekhof <a.f.eekhof at uva.nl>
Datum: maandag 13 april 2026 om 16:44
Aan: Amsterdam Brain Cognition <info-abc at uva.nl>, "Hubregtse, K. (Kim)" <k.hubregtse at vu.nl>, Secretariaat <secretariaat at nin.knaw.nl>, Amsterdam Neuroscience <neuroscience at amsterdamumc.nl>
Onderwerp: Tuesday 14 April 16.00 - 17.00 room D1.111, Science Park 904, 1098 XH Amsterdam ABC & SILS Center for Neuroscience - Seminar By Dr. Matthijs oude Lohuis




You are cordially invited to attend the following SILS/Cognitive and Systems Neuroscience Seminar:



Dissecting feedforward and feedback communication in cortical circuits underlying visual perception



By Dr. Matthijs oude Lohuis


Champalimaud Research, Lisbon, Portugal
Joint postdoc in Cortical Circuits Lab (Leopoldo Petreanu) and Theoretical Neuroscience (Christian Machens)



Hosts: Cyriel Pennartz & Umberto Olcese

Date: Tuesday, 14 April 2026

Time: 16:00 – 17:00 hrs

Location: Room D1.111, Science Park 904

Faculty of Science, University of Amsterdam



Abstract



Abstract:

Visual perception depends on coordinated interactions across cortical areas. Although advances in recording techniques and statistical methods now allow us to measure functional connectivity in distributed neuronal populations, how signals are routed across these networks to give rise to perception remains unclear. In this talk I combine mesoscale two-photon imaging, viral tracing, and optogenetic perturbations to dissect signal propagation across interconnected visual cortical areas in awake mice. First, I show that low-dimensional shared variability across areas (so-called communication subspaces) largely reflects behavioral state–related activity (e.g. locomotion). Removing this shared modulation isolates components more closely associated with direct corticocortical projections. Further, I provide in vivo evidence that feedforward and feedback pathways are not independent, but are organized into looped circuits with selective reciprocal communication, consistent with prior connectivity studies. Finally, complementary analyses of endogenous activity fluctuations and optogenetic perturbations reveal that feedforward and feedback pathways have distinct functional effects on sensory tuning: feedforward signals bias additive gain, whereas feedback signals enhance multiplicative gain with distinct effects on the sensory code. Together, these results suggest that direct long-range projections mediate specific, reciprocal (rather than global) communication between cortical areas, with distinct consequences for sensory processing.

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