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<p class="MsoNormal"><span style="mso-fareast-language:EN-US">FYI!<o:p></o:p></span></p>
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<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;color:black;background:white">Kim Hubregtse</span><span style="font-size:11.0pt;color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span lang="EN-US" style="font-size:10.0pt;color:#0077B3;background:white">PhD Coordinator, Center for Neurogenomics and Cognitive Research (CNCR) | </span><span style="font-size:10.0pt;color:#1F497D;background:white"><a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__www.fga.cncr.nl_&d=DwMGaQ&c=euGZstcaTDllvimEN8b7jXrwqOf-v5A_CdpgnVfiiMM&r=9OwVS9X1FxVRZt8kWeXGFQ&m=-x3i2BCg8s4pBUcB2KYY_SpPEm8PaDLe7duFCHZCuYw&s=b-wMtP4X2ETFG4ZicQd-um8A3-gQc2MTW3iGEPWkgjE&e=" title="https://urldefense.proofpoint.com/v2/url?u=http-3A__www.fga.cncr.nl_&d=DwMGaQ&c=euGZstcaTDllvimEN8b7jXrwqOf-v5A_CdpgnVfiiMM&r=9OwVS9X1FxVRZt8kWeXGFQ&m=-x3i2BCg8s4pBUcB2KYY_SpPEm8PaDLe7duFCHZCuYw&s=b-wMtP4X2ETFG4ZicQd-um8A3-gQc2MTW3iGEPWkgjE&e="><span lang="EN-US" style="color:#1F497D">cncr.nl</span></a></span><span lang="EN-US" style="font-size:10.0pt;color:#0077B3;background:white"> <br>
Coordinator Graduate School Neurosciences Amsterdam Rotterdam (ONWAR</span><span lang="EN-US" style="font-size:10.0pt;color:#2E74B5;background:white">) |</span><span lang="EN-US" style="font-size:10.0pt;color:black;background:white"> </span><span style="font-size:10.0pt;color:#1F497D;background:white"><a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__www.onwar.nl_&d=DwMGaQ&c=euGZstcaTDllvimEN8b7jXrwqOf-v5A_CdpgnVfiiMM&r=9OwVS9X1FxVRZt8kWeXGFQ&m=-x3i2BCg8s4pBUcB2KYY_SpPEm8PaDLe7duFCHZCuYw&s=d_7gS0pVlzuH00hbTRS8R3N7UxlmHoSWkzxF3C3rFZA&e=" title="https://urldefense.proofpoint.com/v2/url?u=http-3A__www.onwar.nl_&d=DwMGaQ&c=euGZstcaTDllvimEN8b7jXrwqOf-v5A_CdpgnVfiiMM&r=9OwVS9X1FxVRZt8kWeXGFQ&m=-x3i2BCg8s4pBUcB2KYY_SpPEm8PaDLe7duFCHZCuYw&s=d_7gS0pVlzuH00hbTRS8R3N7UxlmHoSWkzxF3C3rFZA&e="><span lang="EN-US" style="color:#1F497D">onwar.nl</span></a></span><span lang="EN-US" style="font-size:10.0pt;color:#1F497D;background:white"> </span><b><span lang="EN-US" style="font-size:10.0pt;color:black;background:white"> </span></b><span style="font-size:11.0pt;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;color:black;background:white">Working days: </span></b><span style="font-size:10.0pt;color:black;background:white">Mo, Tu, We, Th, Fr |</span><span style="font-size:10.0pt;color:#0070C0;background:white"> </span><span lang="EN-US" style="font-size:10.0pt;color:#0070C0;background:white"><a href="mailto:k.hubregtse@vu.nl" title="mailto:k.hubregtse@vu.nl">k.hubregtse@vu.nl</a></span><span lang="EN-US" style="font-size:10.0pt;color:black;background:white"> | <b>T:</b> +31
205980955</span><span style="font-size:10.0pt;color:black"><br>
<b><span style="background:white">Mailing address:</span></b><span style="background:white"> De Boelelaan 110</span></span><span lang="EN-US" style="font-size:10.0pt;color:black;background:white">0</span><span style="font-size:10.0pt;color:black;background:white">,
1081 H</span><span lang="EN-US" style="font-size:10.0pt;color:black;background:white">Z </span><span style="font-size:10.0pt;color:black;background:white">Amsterdam</span><span style="font-size:10.0pt;color:black"><br>
<b><span style="background:white">Visiting address:</span></b><span style="background:white"> </span></span><span lang="EN-US" style="font-size:10.0pt;color:black;background:white">VUO 8B-145 </span><span style="font-size:10.0pt;color:black;background:white">| </span><span style="font-size:10.0pt;color:#0070C0;background:white"><a href="https://vu.nl/en/about-vu/more-about/about-the-vu-website" target="new" title="https://vu.nl/en/about-vu/more-about/about-the-vu-website"><span style="color:#0070C0">E-mail
disclaimer</span></a> </span><span style="font-size:10.0pt;color:black;background:white">| </span><span style="font-size:10.0pt;color:#0070C0;background:white"><a href="https://vu.nl/en/" target="new" title="https://vu.nl/en/"><span style="color:#0070C0">www.vu.nl</span></a></span><span style="font-size:11.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif;color:black">Van:
</span></b><span style="font-family:"Calibri",sans-serif;color:black">Aly Eekhof <a.f.eekhof@uva.nl><br>
<b>Datum: </b>maandag 13 april 2026 om 16:44<br>
<b>Aan: </b>Amsterdam Brain Cognition <info-abc@uva.nl>, "Hubregtse, K. (Kim)" <k.hubregtse@vu.nl>, Secretariaat <secretariaat@nin.knaw.nl>, Amsterdam Neuroscience <neuroscience@amsterdamumc.nl><br>
<b>Onderwerp: </b>Tuesday 14 April 16.00 - 17.00 room D1.111, Science Park 904, 1098 XH Amsterdam ABC & SILS Center for Neuroscience - Seminar By Dr. Matthijs oude Lohuis<o:p></o:p></span></p>
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<p align="center" style="text-align:center"><span style="font-size:16.0pt;font-family:"Times New Roman",serif">You are cordially invited to attend the following SILS/Cognitive and Systems Neuroscience Seminar:</span><o:p></o:p></p>
<p align="center" style="text-align:center"><b><span style="font-size:20.0pt;font-family:"Times New Roman",serif"> </span></b><o:p></o:p></p>
<p align="center" style="text-align:center"><b><span style="font-size:18.0pt;font-family:"Times New Roman",serif;color:#222222;background:white">Dissecting feedforward and feedback communication in cortical circuits underlying visual perception</span></b><b><span style="font-size:18.0pt;font-family:"Times New Roman",serif"> </span></b><o:p></o:p></p>
<p align="center" style="text-align:center"><b><span style="font-size:16.0pt;font-family:"Times New Roman",serif"> </span></b><o:p></o:p></p>
<p align="center" style="text-align:center"><span style="font-size:16.0pt;font-family:"Times New Roman",serif">By Dr.
<b>Matthijs oude Lohuis</b></span><o:p></o:p></p>
<p align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:"Times New Roman",serif"> </span><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:13.5pt;font-family:"Times New Roman",serif;color:#222222">Champalimaud Research, Lisbon, Portugal</span><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:13.5pt;font-family:"Times New Roman",serif;color:#222222">Joint postdoc in Cortical Circuits Lab (Leopoldo Petreanu) and Theoretical Neuroscience (Christian Machens)</span><o:p></o:p></p>
<p align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:"Times New Roman",serif"> </span><o:p></o:p></p>
<p align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:"Times New Roman",serif">Hosts: Cyriel Pennartz & Umberto Olcese</span><o:p></o:p></p>
<p class="elementtoproof" align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:"Times New Roman",serif">Date: Tuesday, 14 April 2026</span><o:p></o:p></p>
<p align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:"Times New Roman",serif">Time: 16:00 – 17:00 hrs</span><o:p></o:p></p>
<p align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:"Times New Roman",serif">Location: Room D1.111, Science Park 904</span><o:p></o:p></p>
<p align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:"Times New Roman",serif">Faculty of Science, University of Amsterdam</span><o:p></o:p></p>
<p align="center" style="text-align:center"><b><span style="font-size:14.0pt;font-family:"Times New Roman",serif"> </span></b><o:p></o:p></p>
<p align="center" style="text-align:center"><b><span style="font-size:14.0pt;font-family:"Times New Roman",serif">Abstract</span></b><o:p></o:p></p>
<p align="center" style="text-align:center"><b><span style="font-size:14.0pt;font-family:"Times New Roman",serif"> </span></b><o:p></o:p></p>
<p><b><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Abstract:</span></b><o:p></o:p></p>
<p><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#222222;background:white">Visual perception depends on coordinated interactions across cortical areas. Although advances in recording techniques and statistical methods now allow us to measure
functional connectivity in distributed neuronal populations, how signals are routed across these networks to give rise to perception remains unclear. In this talk I combine mesoscale two-photon imaging, viral tracing, and optogenetic perturbations to dissect
signal propagation across interconnected visual cortical areas in awake mice. First, I show that low-dimensional shared variability across areas (so-called communication subspaces) largely reflects behavioral state–related activity (e.g. locomotion). Removing
this shared modulation isolates components more closely associated with direct corticocortical projections. Further, I provide in vivo evidence that feedforward and feedback pathways are not independent, but are organized into looped circuits with selective
reciprocal communication, consistent with prior connectivity studies. Finally, complementary analyses of endogenous activity fluctuations and optogenetic perturbations reveal that feedforward and feedback pathways have distinct functional effects on sensory
tuning: feedforward signals bias additive gain, whereas feedback signals enhance multiplicative gain with distinct effects on the sensory code. Together, these results suggest that direct long-range projections mediate specific, reciprocal (rather than global)
communication between cortical areas, with distinct consequences for sensory processing.</span><o:p></o:p></p>
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