[Onwar-phd] FW: 4 Sep 17:00 Seminar Series prof. Claudia Clopath online

[Hubregtse, K. (Kim)]

Theory of neural perturbome

Claudia Clopath

Dear all,

You are cordially invited to the online Seminar Series of the Department of Neuroscience , Erasmus MC, with speaker Prof. Claudia Clopath<https://www.imperial.ac.uk/people/c.clopath> of Bioengineering Department, Imperial College London, UK.  The seminar will be hosted by Dr. Aleksandra Badura. See title and abstract below. This information is also on our website neuro.nl.



Monday, 4th of September



17:00 – 18:00 Lecture prof. Claudia Clopath followed by Q&A





Join Zoom Meeting be recognizable by name and preferably by video as well

https://eur-nl.zoom.us/j/96334626146?pwd=Qy9qaHRXVkJrTFQxY3dWUTg3WEw2QT09

Meeting ID: 963 3462 6146

Passcode: 270630

Abstract: To unravel the functional properties of the brain, we need to untangle how neurons interact with each other and coordinate in large-scale recurrent networks. One way to address this question is to measure the functional influence of individual neurons on each other by perturbing them in vivo. Application of such single-neuron perturbations in mouse visual cortex has recently revealed feature-specific suppression between excitatory neurons, despite the presence of highly specific excitatory connectivity, which was deemed to underlie feature-specific amplification. Here, we studied which connectivity profiles are consistent with these seemingly contradictory observations, by modeling the effect of single-neuron perturbations in large-scale neuronal networks. Our numerical simulations and mathematical analysis revealed that, contrary to the prima facie assumption, neither inhibition dominance nor broad inhibition alone were sufficient to explain the experimental findings; instead, strong and functionally specific excitatory–inhibitory connectivity was necessary, consistent with recent findings in the primary visual cortex of rodents. Such networks had a higher capacity to encode and decode natural images, and this was accompanied by the emergence of response gain nonlinearities at the population level. Our study provides a general computational framework to investigate how single-neuron perturbations are linked to cortical connectivity and sensory coding and paves the road to map the perturbome of neuronal networks in future studies.

We look forward to welcome you at the online seminar.

­­­Secretariat Department of Neuroscience

Mandy Mahmoed

Erasmus MC

RM Neuroscience EUR is inviting you to a scheduled Zoom meeting.



Topic: Seminar Series Prof. Claudia Clopath 16:00 Q&A PhD's / 17: 00 Lecture

Time: Sep 4, 2023 03:30 PM CET



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Meeting ID: 963 3462 6146

Passcode: 270630



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