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<b><span lang="EN-GB" style="font-size:16.0pt;line-height:120%;font-family:"Calibri",sans-serif;color:#1F497D">Theory of neural perturbome</span></b><b><span lang="EN-GB" style="font-family:Courier"><o:p></o:p></span></b></p>
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<b><span style="font-size:16.0pt;line-height:120%;font-family:"Calibri",sans-serif;color:#1F497D">Claudia Clopath</span></b><b><span style="font-size:16.0pt;line-height:120%;font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></b></p>
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<p class="xxxmsonormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Dear all,
</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="NoParagraphStyle" style="text-align:justify"><span style="font-size:11.0pt;line-height:120%;font-family:"Calibri",sans-serif;color:windowtext">You are cordially invited to the online Seminar Series of the Department of Neuroscience , Erasmus MC, with
speaker <b><a href="https://www.imperial.ac.uk/people/c.clopath"><span style="color:windowtext;font-weight:normal">Prof. Claudia Clopath</span></a>
</b>of<b> </b></span><span class="contentpasted0"><span style="font-family:"Calibri",sans-serif;letter-spacing:-.05pt;background:white">Bioengineering Department, Imperial College London, UK. </span></span><span style="font-size:11.0pt;line-height:120%;font-family:"Calibri",sans-serif;color:windowtext">The
seminar will be hosted by Dr. Aleksandra Badura. See title and abstract below. This information is also on our website neuro.nl.<o:p></o:p></span></p>
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<b><span style="font-size:11.0pt;line-height:120%;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></b></p>
<p class="xxxmsonormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Monday, 4<sup>th</sup> of September<o:p></o:p></span></p>
<p class="xxxmsonormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
<p class="xxxmsonormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif">17:00 – 18:00 Lecture<span style="color:#1F497D">
</span>prof. Claudia Clopath followed by Q&A <o:p></o:p></span></p>
<p class="xxxmsonormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p class="xxxmsonormal"><span lang="EN-US" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p> </o:p></span></p>
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<p class="xxxmsonormal"><span style="font-size:9.0pt;font-family:"Calibri",sans-serif;color:black">Join Zoom Meeting be recognizable by name and preferably by video as well</span><span style="font-size:9.0pt"><o:p></o:p></span></p>
<p class="xxxmsonormal"><span style="font-size:9.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><a href="https://eur-nl.zoom.us/j/96334626146?pwd=Qy9qaHRXVkJrTFQxY3dWUTg3WEw2QT09">https://eur-nl.zoom.us/j/96334626146?pwd=Qy9qaHRXVkJrTFQxY3dWUTg3WEw2QT09</a><o:p></o:p></span></p>
<p class="xxxmsonormal"><span style="font-size:9.0pt;font-family:"Calibri",sans-serif;color:black">Meeting ID:
</span><span style="font-size:9.0pt;font-family:"Calibri",sans-serif;color:#1F497D;letter-spacing:.3pt;background:#DEEAF6">963 3462 6146</span><span style="font-size:9.0pt"><o:p></o:p></span></p>
<p class="xxxmsonormal"><span style="font-size:9.0pt;font-family:"Calibri",sans-serif;color:black">Passcode:
</span><span style="font-size:9.0pt;font-family:"Calibri",sans-serif;color:#1F497D">270630</span><o:p></o:p></p>
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<p class="xxxmsonormal" style="margin-bottom:14.0pt"><span style="font-size:8.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><br>
</span><span style="font-size:9.0pt;font-family:"Calibri",sans-serif">Abstract: </span>
<span style="font-size:9.0pt;font-family:"Arial",sans-serif;color:black;background:white">To unravel the functional properties of the brain, we need to untangle how neurons interact with each other and coordinate in large-scale recurrent networks. One way to
address this question is to measure the functional influence of individual neurons on each other by perturbing them in vivo. Application of such single-neuron perturbations in mouse visual cortex has recently revealed feature-specific suppression between excitatory
neurons, despite the presence of highly specific excitatory connectivity, which was deemed to underlie feature-specific amplification. Here, we studied which connectivity profiles are consistent with these seemingly contradictory observations, by modeling
the effect of single-neuron perturbations in large-scale neuronal networks. Our numerical simulations and mathematical analysis revealed that, contrary to the prima facie assumption, neither inhibition dominance nor broad inhibition alone were sufficient to
explain the experimental findings; instead, strong and functionally specific excitatory–inhibitory connectivity was necessary, consistent with recent findings in the primary visual cortex of rodents. Such networks had a higher capacity to encode and decode
natural images, and this was accompanied by the emergence of response gain nonlinearities at the population level. Our study provides a general computational framework to investigate how single-neuron perturbations are linked to cortical connectivity and sensory
coding and paves the road to map the perturbome of neuronal networks in future studies.</span><span style="font-size:9.0pt;font-family:"Arial",sans-serif;color:#777777;background:white"><o:p></o:p></span></p>
<p class="xxxmsonormal" style="margin-bottom:14.0pt"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">We look forward to welcome you at the<span style="color:#1F497D">
</span>online seminar.</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="xxxmsonormal" style="margin-bottom:7.5pt"><span style="color:#1F497D"></span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Secretariat Department of Neuroscience</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="xxxmsonormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Mandy Mahmoed</span><o:p></o:p></p>
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<p class="xxxmsonormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Erasmus MC</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
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<p class="xxxmsonormal"><span style="color:#1F497D">RM Neuroscience EUR is inviting you to a scheduled Zoom meeting.<o:p></o:p></span></p>
<p class="xxxmsonormal"><span style="color:#1F497D"><o:p> </o:p></span></p>
<p class="xxxmsonormal"><span style="color:#1F497D">Topic: <b>Seminar Series Prof. Claudia Clopath 16:00 Q&A PhD's / 17: 00 Lecture<o:p></o:p></b></span></p>
<p class="xxxmsonormal"><b><span style="color:#1F497D">Time: Sep 4, 2023 03:30 PM CET<o:p></o:p></span></b></p>
<p class="xxxmsonormal"><b><span style="color:#1F497D"><o:p> </o:p></span></b></p>
<p class="xxxmsonormal"><b><span style="color:#1F497D">Join Zoom Meeting<o:p></o:p></span></b></p>
<p class="xxxmsonormal"><b><span style="color:#1F497D"><a href="https://eur-nl.zoom.us/j/96334626146?pwd=Qy9qaHRXVkJrTFQxY3dWUTg3WEw2QT09">https://eur-nl.zoom.us/j/96334626146?pwd=Qy9qaHRXVkJrTFQxY3dWUTg3WEw2QT09</a><o:p></o:p></span></b></p>
<p class="xxxmsonormal"><b><span style="color:#1F497D"><o:p> </o:p></span></b></p>
<p class="xxxmsonormal"><b><span style="color:#1F497D">Meeting ID: 963 3462 6146<o:p></o:p></span></b></p>
<p class="xxxmsonormal"><b><span style="color:#1F497D">Passcode: 270630<o:p></o:p></span></b></p>
<p class="xxxmsonormal"><span style="color:#1F497D"><o:p> </o:p></span></p>
<p class="xxxmsonormal"><span style="color:#1F497D">---<o:p></o:p></span></p>
<p class="xxxmsonormal"><span style="color:#1F497D"><o:p> </o:p></span></p>
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<p class="xxxmsonormal"><span style="color:#1F497D">Passcode: 270630<o:p></o:p></span></p>
<p class="xxxmsonormal"><span style="color:#1F497D"><o:p> </o:p></span></p>
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<span style="font-size:8.5pt;line-height:150%;font-family:Helvetica;color:#767171">This emaill is from</span><span style="font-family:Helvetica;color:#767171">
</span><span style="font-size:12.0pt;line-height:150%"><a href="mailto:neuroscience@erasmusmc.nl"><span style="font-size:10.0pt;line-height:150%;color:#767171">neuroscience</span><span style="font-size:10.0pt;line-height:150%;font-family:Helvetica;color:#767171">@erasmusmc.nl</span></a></span><span style="font-size:8.5pt;line-height:150%;font-family:Helvetica;color:#767171">
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</span><span style="font-size:12.0pt;line-height:150%"><a href="https://neuro.us17.list-manage.com/about?u=db5fd793d0c0b22699f218151&id=97ba9f95c8&e=__test_email__&c=934468cd76" target="_blank"><em><span style="font-size:8.5pt;line-height:150%;font-family:Helvetica;color:#767171">why
did I get this?</span></em></a></span><span style="font-size:8.5pt;line-height:150%;font-family:Helvetica;color:#767171">
</span><span style="font-size:12.0pt;line-height:150%"><a href="https://neuro.us17.list-manage.com/profile?u=db5fd793d0c0b22699f218151&id=97ba9f95c8&e=__test_email__&c=934468cd76"><span style="font-size:8.5pt;line-height:150%;font-family:Helvetica;color:#767171">update
subscription preferences</span></a></span><span style="font-size:8.5pt;line-height:150%;font-family:Helvetica;color:#767171">
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</span><span style="font-size:8.5pt;line-height:150%;font-family:Helvetica;color:#767171">Neuroscience Erasmus MC · Dr. Molewaterplein 40 · Rotterdam, Zh 3015 GE · Netherlands
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