[Jongkees-group.beta] FW: 500 MHz Spectrometer

[Jongkees, S.A.K. (Seino)]

Seino A. K. Jongkees, Ph.D.
Associate Professor
AIMMS Amsterdam Institute of Molecular and Life Sciences
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T +31 (0)6 5722 7168 | http://sakjongkees.wixsite.com/website | s.a.k.jongkees at vu.nl
Vrije Universiteit Amsterdam, Chemistry and Pharmaceutical Sciences, O|2 building
O2-03W51, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands

From: Janssen, A.C. (Elwin) <a.c.janssen at vu.nl>
Sent: Wednesday, 22 March 2023 12:05 pm
To: Beta Syborch <syborch.beta at vu.nl>; BETA Medicinal Chemistry - Design And Synthesis <mecdes.synth.beta at vu.nl>; _list_jongkees-group.beta-bounces <jongkees-group.beta-bounces at listserver.vu.nl>; Korat, Š. (Špela) <s.korat at amsterdamumc.nl>; Schatte Olivier, H.A. van der (Anne) <h.vanderschatteolivier at vumc.nl>; Bier, P.M. <p.bier at amsterdamumc.nl>; Moco, S. (Sofia) <s.moco at vu.nl>; Poole, D.A. (David) <d.a.poole at vu.nl>; Niels Sijbrandi <sijbrandi at linxispharmaceuticals.com>; Hamilton, D.J. (David) <d.j.hamilton at vu.nl>
Cc: Vernimmen, J. (Jacky) <j.vernimmen at vu.nl>
Subject: 500 MHz Spectrometer

Hello NMR users,

Some of you might have noticed that the integrals (belonging to a single compound) in 1H spectra recorded on the 500 do not show an optimal relation to another. In the 1H spectra the integrals in the higher frequency region (aromatic) are in general between 10-20% lower than in the lower frequency region. Though the spectra still look very good and can still be used to quite an extend for qualitative analyses, it is a serious issue for quantitative experiments.

Therefore, do not use the 500 for quantitative analyses. You can still use the 300 and, when authorized, the 600 for these types of experiments.

Sadly, this is a hardware issue that I cannot fix and Bruker has replaced the involved modules with no effect. I am working on a solution.

Please let me know if you have any questions.

Best,

Elwin

Elwin (A.C.) Janssen
NMR Facility Manager|Lecturer
Vrije Universiteit Amsterdam
Department of Chemistry & Pharmaceutical Sciences
AIMMS Amsterdam Institute of Molecular and Life Sciences
T +31 (0)20 59 87489| a.c.janssen at vu.nl<mailto:a.c.janssen at vu.nl>| Disclaimer<https://www.vu.nl/nl/over-de-vu/vu-website/e-mail-disclaimer/index.aspx>
MAILING ADDRESS: De Boelelaan 1105, 1081HV Amsterdam
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