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<p class="p1"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Dear ONWAR students,<o:p></o:p></span></p>
<p class="p1"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p class="p1"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">We are delighted to extend a warm welcome to the upcoming Swammerdam Lecture!
<o:p></o:p></span></p>
<p class="p1"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Please take a moment to read the email below for important details.<o:p></o:p></span></p>
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<span style="font-size:20.0pt;font-family:Raleway;color:white;text-transform:uppercase"> </span><o:p></o:p></p>
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<b><span style="font-size:14.5pt;font-family:Raleway;color:white;font-style:normal"><br>
</span></b><span style="font-size:14.5pt;font-family:Raleway;color:white">SWAMMERDAM LECTURE</span><o:p></o:p></h4>
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<b><span style="font-size:11.0pt;color:black;font-style:normal"> </span></b><o:p></o:p></h4>
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<b><span style="font-size:14.5pt;font-family:Raleway;color:white;font-style:normal"><img width="221" height="191" style="width:2.302in;height:1.9895in" id="Picture_x0020_1" src="cid:image001.png@01DA602F.35C010C0" alt="A person sitting in a chair
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</span></b><b><span lang="NL" style="font-size:14.5pt;font-family:Raleway;color:white">Thursday April 18th</span></b><b><span style="font-size:14.5pt;font-family:Raleway;color:white"> 202</span></b><b><span lang="NL" style="font-size:14.5pt;font-family:Raleway;color:white">4
</span></b><b><span style="font-size:14.5pt;font-family:Raleway;color:white">at 16:00</span></b><o:p></o:p></h4>
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<b><span style="font-size:14.5pt;font-family:Raleway;color:white"> </span></b><o:p></o:p></h4>
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<span style="font-size:15.0pt;font-family:Raleway;color:white">Prof. dr. Alexe</span><span lang="EN-US" style="font-size:15.0pt;font-family:Raleway;color:white">i</span><span style="font-size:15.0pt;font-family:Raleway;color:white"> Verhratsk</span><span lang="EN-US" style="font-size:15.0pt;font-family:Raleway;color:white">y</span><o:p></o:p></h4>
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<span style="font-size:14.5pt;font-family:Raleway;color:white;font-weight:normal">“</span><span lang="EN-US" style="font-size:14.5pt;font-family:Raleway;color:white;font-weight:normal">Pathophysiology of astroglia”</span><o:p></o:p></h2>
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<strong><span style="font-size:10.5pt;font-family:Montserrat;color:white">Affiliation</span></strong><o:p></o:p></p>
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<span style="font-size:10.5pt;font-family:Montserrat;color:white;background:#5A60A8">Achucarro Basque Center for Neuroscience</span><span lang="EN-US" style="font-size:10.5pt;font-family:Montserrat;color:white;background:#5A60A8">,
</span><span style="font-size:10.5pt;font-family:Montserrat;color:white;background:#5A60A8">Leioa, Spain</span><span lang="EN-US" style="font-size:10.5pt;font-family:Montserrat;color:white;background:#5A60A8"> and
</span><span lang="EN-US" style="font-size:10.5pt;font-family:Montserrat;color:white">University of
</span><span style="font-size:10.5pt;font-family:Montserrat;color:white;background:#5A60A8">Manchester</span><span lang="EN-US" style="font-size:10.5pt;font-family:Montserrat;color:white">, UK</span><o:p></o:p></p>
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<strong><span style="font-size:10.5pt;font-family:Montserrat;color:white">Date / time</span></strong><o:p></o:p></p>
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<p style="vertical-align:baseline;box-sizing:border-box;font-style:inherit;font-weight:inherit;outline:0px">
<span lang="EN-GB" style="font-size:10.5pt;font-family:Montserrat;color:white">Lecture on April 18<sup>th</sup> 2024 16:00-17:00<br>
In addition, more information on a Masterclass with prof. dr. Verhratsky<span class="apple-converted-space"> </span>can be found below and on the ONWAR website.</span><o:p></o:p></p>
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<strong><span style="font-size:10.5pt;font-family:Montserrat;color:white">Host</span></strong><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.5pt;font-family:Montserrat;color:white">prof. dr. Eleonora Aronica</span><o:p></o:p></p>
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<strong><span style="font-size:10.5pt;font-family:Montserrat;color:white">Locati</span></strong><strong><span lang="NL" style="font-size:10.5pt;font-family:Montserrat;color:white">o</span></strong><strong><span style="font-size:10.5pt;font-family:Montserrat;color:white">n</span></strong><o:p></o:p></p>
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<span lang="EN-US" style="font-size:10.5pt;font-family:Montserrat;color:white">Netherlands Institute for Neuroscience, Colloquium Room, Meibergdreef 47, Amsterdam</span><o:p></o:p></p>
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<strong><span style="font-size:10.5pt;font-family:Montserrat;color:white">Zoom link</span></strong><o:p></o:p></p>
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<p style="margin-bottom:16.8pt;vertical-align:baseline"><span lang="EN-US" style="font-size:10.5pt;font-family:Montserrat;color:white">The Swammerdam lectures will be held live. If you are not able to attend, please send an email to<span class="apple-converted-space"> </span><a href="mailto:k.hubregtse@vu.nl" title="mailto:k.hubregtse@vu.nl"><span style="color:white;text-decoration:none">k.hubregtse@vu.nl</span></a>.
Please keep in mind that the Swammerdam Lectures are<span class="apple-converted-space"> </span><b>mandatory</b>.<span class="apple-converted-space"> </span></span><o:p></o:p></p>
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<p style="margin-bottom:16.8pt;background:#5A60A8;vertical-align:baseline"><span style="font-size:11.0pt;color:black"> </span><o:p></o:p></p>
<p style="margin-bottom:16.8pt;background:#5A60A8;vertical-align:baseline"><span style="font-size:10.5pt;font-family:Montserrat;color:white">Astroglia are a broad class of neural parenchymal cells primarily dedicated to homeostasis and defence of the central
nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in ways that can be either beneficial or detrimental to disorder outcome. Pathophysiological changes in astroglia can be primary or secondary
and can result in gain or loss of functions. Astroglia respond to external, non-cell autonomous signals associated with any form of CNS pathology by undergoing complex and variable changes in their structure, molecular expression, and function. In addition,
internally driven, cell autonomous changes of astroglial innate properties can lead to CNS pathologies. Astroglial pathophysiology is complex, with different pathophysiological cell states and cell phenotypes that are context-specific and vary with disorder,
disorder-stage, comorbidities, age, and sex. Astroglial pathophysiology is classified into (i) reactive astrogliosis, (ii) astroglial atrophy with loss of function, (iii) astroglial degeneration and death, and (iv) astrocytopathies characterised by aberrant
forms that drive disease. Characterising cellular and molecular mechanisms of astroglial pathophysiology represents a new frontier to identify novel therapeutic strategies.</span><o:p></o:p></p>
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<b><span style="font-size:14.0pt;font-family:Raleway;color:white">Masterclass</span></b><o:p></o:p></h4>
<p style="margin-bottom:16.8pt;background:#5A60A8;vertical-align:baseline;box-sizing:border-box;outline:0px;font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px">
<span style="font-size:10.5pt;font-family:Montserrat;color:white">Preceding the Swammerdam Lecture on April 18, 2024 of Prof. <strong><span style="font-family:Montserrat">Alexei Verkhratsky</span></strong> (Science Park of the UPV/EHU Sede Building, Leioa Spain)
at the Netherlands Institute for Neuroscience (NIN) will chair a Masterclass from 13:00-16:00. A selected group of PhD students with an interest in the field of <em><b><span style="font-family:Montserrat">Pathophysiology of Astroglia </span></b></em>will have
the opportunity to present their work and discuss their results and ideas with Alexei Verkhratsky.</span><o:p></o:p></p>
<p style="margin-bottom:16.8pt;background:#5A60A8;vertical-align:baseline;box-sizing:border-box;outline:0px;font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px">
<span style="font-size:10.5pt;font-family:Montserrat;color:white">PhD students from the Graduate School Neurosciences Amsterdam Rotterdam (ONWAR) are encouraged to submit an abstract</span><span style="font-size:10.5pt;font-family:Montserrat;color:black">
</span><span style="font-size:10.5pt;font-family:Montserrat;color:white;background:#5A60A8">to prof. dr. Eleonora Aronica (</span><span style="font-size:10.5pt;font-family:Montserrat;color:#83CBEB;background:#5A60A8"><a href="mailto:e.aronica@amsterdamumc.nl"><span style="color:#83CBEB">e.aronica@amsterdamumc.nl</span></a></span><span style="font-size:10.5pt;font-family:Montserrat;color:white;background:#5A60A8">)
from 19 February </span><span lang="EN-US" style="font-size:10.5pt;font-family:Montserrat;color:white;background:#5A60A8">un</span><span style="font-size:10.5pt;font-family:Montserrat;color:white;background:#5A60A8">til 20 March</span><span style="font-size:10.5pt;font-family:Montserrat;color:white">.
The selected students will be invited to have lunch with Prof. Verkhratsky preceding the Masterclass.</span><o:p></o:p></p>
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<span style="color:black"> </span><o:p></o:p></p>
<p class="xxxmsonormal" style="margin:0cm;vertical-align:baseline"><span style="font-size:12.0pt;font-family:Montserrat;color:#1F1D21"> </span><o:p></o:p></p>
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<i><span lang="EN-US" style="font-size:9.0pt;font-family:Montserrat;color:white">This is a lecture provided by the graduate school ONWAR</span></i><o:p></o:p></p>
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<span style="color:black"> </span><o:p></o:p></p>
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<span style="font-size:14.5pt;font-family:Montserrat;color:white"><img border="0" width="150" height="150" style="width:1.5625in;height:1.5625in" id="Picture_x0020_3" src="cid:image002.png@01DA602F.35C010C0" alt="cid90405*image002.png@01D94DEF.CFC643E0"></span><o:p></o:p></p>
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<span style="font-size:10.5pt;color:white">For a list of all upcoming Swammerdam Lectures and Masterclasses, see<span class="xxxapple-converted-space"> </span></span><span style="color:black"><a href="https://www.onwar.nl/?page_id=1582" title="https://www.onwar.nl/?page_id=1582"><span style="font-size:10.5pt;color:white">our
website</span></a></span><o:p></o:p></p>
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