<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=Windows-1252">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:Helvetica;
panose-1:0 0 0 0 0 0 0 0 0 0;}
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Aptos;
panose-1:2 11 0 4 2 2 2 2 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
font-size:10.0pt;
font-family:"Calibri",sans-serif;}
span.EmailStyle19
{mso-style-type:personal-reply;
font-family:"Calibri",sans-serif;
color:windowtext;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;
mso-ligatures:none;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:72.0pt 72.0pt 72.0pt 72.0pt;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="en-NL" link="#0563C1" vlink="#954F72" style="word-wrap:break-word">
<div class="WordSection1">
<p class="MsoNormal"><span lang="EN-US" style="font-size:11.0pt;mso-fareast-language:EN-US">Could be interesting<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<div>
<div>
<p class="MsoNormal"><span lang="EN-US" style="font-size:7.5pt;font-family:"Arial",sans-serif;color:black">Seino A. K. Jongkees, Ph.D.</span><span style="font-size:11.0pt;color:#212121"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:7.5pt;font-family:"Arial",sans-serif;color:black">Associate Professor</span><span style="font-size:11.0pt;color:#212121"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:7.5pt;font-family:"Arial",sans-serif;color:#0089CF">AIMMS Amsterdam Institute of Molecular and Life Sciences</span><span style="font-size:11.0pt;color:#212121"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:black"><img width="312" height="63" style="width:3.25in;height:.6562in" id="Picture_x0020_1" src="cid:image002.png@01DA21FC.27549220" alt="email_vu_logo_aimms_en.png"></span><span style="font-size:11.0pt;color:#212121"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:7.5pt;font-family:"Arial",sans-serif;color:#5B5B5B">T <a href="tel:+31657227168"><span style="color:#0078D7">+31 (0)6 5722 7168</span></a> | </span><span lang="EN-US" style="font-size:8.5pt;font-family:Helvetica;color:#4472C4"><a href="http://sakjongkees.wixsite.com/website"><span style="color:#0078D7">http://sakjongkees.wixsite.com/website</span></a></span><span lang="EN-US" style="font-size:7.5pt;font-family:"Arial",sans-serif;color:#5B5B5B"> | </span><span lang="EN-US" style="font-size:8.5pt;font-family:Helvetica;color:#4472C4"><a href="mailto:s.a.k.jongkees@vu.nl"><span style="color:#0078D7">s.a.k.jongkees@vu.nl</span></a></span><span style="font-size:11.0pt;color:#212121"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:7.5pt;font-family:"Arial",sans-serif;color:#5B5B5B">Vrije Universiteit Amsterdam, Chemistry and Pharmaceutical Sciences, O|2 building</span><span style="font-size:11.0pt;color:#212121"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:7.5pt;font-family:"Arial",sans-serif;color:#5B5B5B">O2-03W51, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands</span><span style="font-size:11.0pt;mso-fareast-language:EN-US"><o:p></o:p></span></p>
</div>
</div>
<p class="MsoNormal"><span style="font-size:11.0pt;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<div id="mail-editor-reference-message-container">
<div>
<div style="border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0cm 0cm 0cm">
<p class="MsoNormal" style="margin-bottom:12.0pt"><b><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">From:
</span></b><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">Beta Info Aimms <info@aimms.vu.nl><br>
<b>Date: </b>Tuesday, 28 November 2023 at 13:00<br>
<b>To: </b>Fonseca Guerra, C. (C) <c.fonsecaguerra@vu.nl>, Förster, A.T.L. (Arno) <a.t.l.foerster@vu.nl>, Gerber, A.J. (Alan John) <a.j.gerber@vu.nl>, Franchini, M. (M) <m.franchini@vu.nl>, Gao, M. (Meichun) <m.c.gao@vu.nl>, Gargano, A.F.G. (Andrea) <a.f.g.gargano@vu.nl>,
Ge, J. (Jingjing) <j.ge@vu.nl>, Geballa-Koukoula, A. (Ariadni) <a.geballa-koukoula@vu.nl>, Geerke, D.P. (Daan) <d.p.geerke@vu.nl>, Ghavim, B. (Behrad) <b.ghavim@vu.nl>, Gritsenko, O. (Oleg) <o.gritsenko@vu.nl>, Giesbertz, K.J.H. (Klaas) <k.j.h.giesbertz@vu.nl>,
Gori Giorgi, P. (P) <p.gorigiorgi@vu.nl>, Goumans, T.P.M. (TPM) <t.p.m.goumans@vu.nl>, Gran Scheuch, A.A. (Alejandro Alberto) <a.granscheuch@vu.nl>, Hariharan, S. (Seenivasan) <s.hariharan@vu.nl>, Groot, L.C. (Laurens) <l.c.groot@vu.nl>, Grossmann, T.N. (Tom)
<t.n.grossmann@vu.nl>, Haim, A. (Anissa) <a.haim@vu.nl>, Hamlin, T.A. (Trevor) <t.a.hamlin@vu.nl>, Hanreich, S. (Stefanie) <s.hanreich@vu.nl>, Heukers, R.H. (Raimond) <r.heukers@vu.nl>, Hansen, T. (Thomas) <t.hansen@vu.nl>, Harteveld, J.W. (Jaap) <j.w.harteveld@vu.nl>,
Hasanefendic, S. (Sandra) <s.hasanefendic@vu.nl>, Hauwert, N.J. (Niels) <n.j.hauwert@vu.nl>, Hennig, S. (Sven) <s.hennig@vu.nl>, Hes, K. (Kevin) <k.hes@vu.nl>, Hoogstraaten, M.J. (Marjolein) <m.j.hoogstraaten@vu.nl>, Hopstaken, A.J.P. (Twan) <a.j.p.hopstaken@vu.nl>,
Hordijk, Y. (Yuman) <y.hordijk@vu.nl>, JIAXING, L. (Liu) <l.jiaxing@vu.nl>, Horst, B. (Brendan) <b.horst@vu.nl>, Hutchins, G.H.A. (George) <g.h.a.hutchins@vu.nl>, Iglesias Moncayo, M.E. (Maria Emilia) <m.e.iglesiasmoncayo@vu.nl>, Illies, J.H. (Jan Hendrik)
<j.h.illies@vu.nl>, Isakova, E. (Elina) <e.isakova@vu.nl>, Jonker, A.M. (Anika) <a.m.jonker@vu.nl>, Janowiak, N. (Natalia) <n.janowiak@vu.nl>, Jennings, P. (Paul) <p.jennings@vu.nl>, Jongkees, S.A.K. (Seino) <s.a.k.jongkees@vu.nl>, Jongsma, M.V. (Mirella)
<mirella.jongsma@vu.nl>, Jooß, K. (Kevin) <k.jooss@vu.nl>, Josimovic, I. (Ivana) <i.josimovic@vu.nl>, Kerkhoven, A.H. (Anne) <a.h.kerkhoven@vu.nl>, Kets, J. (J) <j.kets@vu.nl>, Khandaviili, S.S. (Srinivasa Sarathchandra) <s.s.khandaviili@vu.nl>, Klatt, O.C.
(Olivia) <o.c.klatt@vu.nl>, Kraakman- - van der Zwet, M. (Ria) <m.van.der.zwet@vu.nl>, Kohler, I. (Isabelle) <i.kohler@vu.nl>, Kontochristou, A. (Amalia) <a.kontochristou@student.vu.nl>, Kooi, D.P. (Derk) <d.p.kooi@vu.nl>, Kool, J. (J) <j.kool@vu.nl>, Koridon,
E.F. (Emiel) <e.f.koridon@vu.nl>, Kruijswijk, J.D. (Jordy) <j.d.kruijswijk@vu.nl>, Kyllesbech, V. (Victor) <v.kyllesbech@vu.nl>, Liu, M.Z. (Meizhe) <m.z.liu@vu.nl>, Lamme, T.D. (Thomas) <t.d.lamme@student.vu.nl>, Lekanne gezegd Deprez, S.J. (Siebe) <s.j.lekanne.deprez@vu.nl>,
Leurs, R. (Rob) <r.leurs@vu.nl>, Li, L.Y. (Yun) <l.y.li@vu.nl>, Lizandra Pérez, J. (Juan) <j.lizandraperez@vu.nl>, Lopez-Lopez, S. (S) <s.lopez-lopez@vu.nl>, Ma, Z.X. (Zhongxuan) <z.x.ma@vu.nl>, Majeed, H.A. (Hany) <h.a.majeed@vu.nl>, Martin, N.S. (Nicolas)
<n.s.martin@vu.nl>, Meijer, T. (Tamara) <t.meijer@vu.nl>, Mobach, S. (Simon) <s.mobach@vu.nl>, Moco, S. (Sofia) <s.moco@vu.nl>, Molenaar, S.R.A. (Stef) <s.r.a.molenaar@vu.nl>, Neubacher, S.A. (Saskia) <s.a.neubacher@vu.nl>, Moloto, B.P. (Bryan Phuti) <b.p.moloto@vu.nl>,
Mousavi, S. (Seyedesmaeil) <s.mousavi@vu.nl>, Murphy, C. (Cormac) <c.murphy@vu.nl>, Nagasundaram, S. (Sathyanarayanan) <s.nagasundaram@vu.nl>, Nesheva, D. (Desislava) <d.nesheva@vu.nl>, Nieuwland, C. (Celine) <c.nieuwland@vu.nl>, Nygren, J.K.O. (Jonatan) <j.k.o.nygren@vu.nl>,
Paulus, J. (Jannik) <j.paulus@vu.nl>, Paulußen, F.M. (Felix) <f.m.paulussen@vu.nl>, Perez Almeria, C.V. (Claudia Victoria) <c.v.perezalmeria@vu.nl>, Pfeil, E.M. (Cy) <c.pfeil@vu.nl>, Philipsen, P.H.T. (PHT) <p.h.t.philipsen@vu.nl>, Poole, D.A. (David) <d.a.poole@vu.nl>,
Pozo García, M.V. (Maria Victoria) <m.v.pozo.garcia@vu.nl>, Randoe, R.E. (Rosa) <r.e.randoe@vu.nl>, Ren, J. (Jiyu) <j.ren@vu.nl>, Rijs, A.M. (Anouk) <a.m.rijs@vu.nl>, Rodrigues Silva, D. (Daniela) <d.rodriguessilva@vu.nl>, Roose, T. (Thomas) <t.r.roose@vu.nl>,
Ruger, R. (R) <r.ruger@vu.nl>, Ruijter, E. (Eelco) <e.ruijter@vu.nl>, Ruiter, J.C. (Jesper) <j.c.ruiter@vu.nl>, Saha, S. (Sneha) <s.s.saha@vu.nl>, Santos Capinha, L.M. (Liliana Monica) <l.santoscapinha@vu.nl>, Sen, S.S. (Souloke) <s.sen@vu.nl>, Sapova, M.
(Mariia) <m.sapova@vu.nl>, Schafer, C.T. (Chris) <c.t.schafer@vu.nl>, Scharapow, N. (Nelli) <n.scharapow@vu.nl>, Scholten, D.J. (DJ) <danny.scholten@vu.nl>, Scuric, E.W.J. (Emma) <e.w.j.scuric@vu.nl>, Seidl, M.W.J. (Michael) <m.w.j.seidl@vu.nl>, Setiawan,
I.M. (Irfan) <i.m.setiawan@vu.nl>, Shi, S. (Shuang) <s.shi@vu.nl>, Siderius, M.H. (MH) <m.siderius@vu.nl>, Smit, M.J. (MJ) <mj.smit@vu.nl>, Soini, T. (Thomas) <t.soini@vu.nl>, Somsen, G.W. (Govert) <g.w.somsen@vu.nl>, Spadetto, E. (Edoardo) <e.spadetto@vu.nl>,
Tibaldi, M. (Marco) <m.tibaldi@vu.nl>, Steen, E.J.L. (Johanna) <e.j.l.steen@vu.nl>, Sterk, J.O. (John) <j.o.sterk@vu.nl>, Still, K.B.M. (Kristina) <k.b.m.still@vu.nl>, Stroganova, I. (Iuliia) <i.stroganova@vu.nl>, Veizaj, D. (Dejvid) <d.veizaj@vu.nl>, Sutter,
S.M. (Sarina Mirjam) <s.m.sutter@vu.nl>, Tiekink, E.H. (Eveline) <e.h.tiekink2@vu.nl>, Tran, T.D. (Thuy Duong) <t.d.tran@vu.nl>, Turina, V. (Valeria) <v.turina@vu.nl>, Tutiš, L. (Luca) <l.tutis@vu.nl>, Uzoamaka Godwin, I.U.G. (Ikenga) <i.u.g.uzoamakagodwin@vu.nl>,
Bor, J. van den (Jelle) <j.vanden.bor@vu.nl>, Vreede, J. (Jocelyne) <j.vreede@vu.nl>, Brekel, V.B.M. van den (Vincent) <v.b.m.van.den.brekel@student.vu.nl>, Heijningen, J.V. van (Joris) <j.v.van.heijningen@vu.nl>, Lenthe, E. van (E) <e.van.lenthe@vu.nl>, Linden,
O.P.J. van (Oscar) <oscar.van.linden@vu.nl>, Windhorst, A.D. (Bert (Albert D.)) <a.d.windhorst@vu.nl>, Muijlwijk - Koezen, J.E. van (Jacqueline) <j.e.van.muijlwijk-koezen@vu.nl>, Scheijen, S. van (Sonja) <s.van.scheijen@vu.nl>, Tonder, C. van (Chanté) <c.vantonder@vu.nl>,
Yamazaki, K.B.Y. (Ken Barrett) <k.b.y.yamazaki@vu.nl>, Verduin, J. (Joshka) <j.verduin@vu.nl>, Vermeeren, P. (Pascal) <p.vermeeren@vu.nl>, Vischer, H.F. (HF) <h.f.vischer@vu.nl>, Visscher, L. (Luuk) <l.visscher@vu.nl>, Visser, O. (O) <o.visser@vu.nl>, Voeten,
R.L.C. (Robert) <r.l.c.voeten@vu.nl>, Vos, J.C. (JC) <j.c.vos@vu.nl>, Wang, S. (Siyu) <s.wang2@vu.nl>, Wang, R. (Rong) <r4.wang@vu.nl>, Wang, H. (Huan) <h.wang@vu.nl>, Weber, P. (Peter) <p.weber@vu.nl>, Weng, X. (Xiangmin) <x.weng@vu.nl>, Hoorn, P. van (Peter)
<p.van.hoorn@vu.nl>, Wijffelaars, L.H.A. (Laura) <l.h.a.wijffelaars@vu.nl>, Wijtmans, M. (Maikel) <m.wijtmans@vu.nl>, Wilmes, A. (Anja) <a.wilmes@vu.nl>, Wu, X. (Xia) <x.wu@vu.nl>, Schoot, J.F. van (JF) <j.f.van.schoot@vu.nl>, Xu, H. (Haifeng) <h.xu@vu.nl>,
Vreumingen, D. van (Dyon) <d.van.vreumingen@vu.nl>, Yakovlev, A.L. (AL) <a.l.yakovlev@vu.nl>, Yang, F. (Fan) <f.yang@vu.nl>, Yeste Vazquez, A. (Alejandro) <a.yestevazquez@vu.nl>, Yoshisada, R. (Ryoji) <r.yoshisada@vu.nl>, Zarzycka, B.A. (Barbara) <b.a.zarzycka@vu.nl>,
Zhang, X. (Xiaoyi) <x.zhang3@vu.nl>, Vies, S.M. van der (Saskia) <s.m.vander.vies@vu.nl>, Abeln, S. (Sanne) <s.abeln@vu.nl>, Bosdriesz, E. (Evert) <e.bosdriesz@vu.nl>, Branco dos Santos, F. (Filipe) <f.brancodossantos@vu.nl>, Feenstra, K.A. (Anton) <k.a.feenstra@vu.nl>,
Gogishvili, D. (Dea) <d.gogishvili@vu.nl>, Hamoen, L.W. (Leendert) <l.w.hamoen@vu.nl>, Haydarlou, A.R. (Reza) <r.haydarlou@vu.nl>, Hoekstra, L. (Laura) <l.hoekstra@vu.nl>, Lakbir, S. (Soufyan) <s.lakbir@vu.nl>, Liu, T. (Ting) <t.liu@vu.nl>, Machado de Faria,
L. (Laura) <l.machado.de.faria@vu.nl>, Mouhib, H. (Halima) <h.mouhib@vu.nl>, Pissis, S. (Solon) <s.pissis@vu.nl>, Postma, M. (Marten) <m2.postma@vu.nl>, Stohn, T. (Tim) <t.stohn@vu.nl>, Waury, K. (Katharina) <k.waury@vu.nl>, Westerhuis, J.A. (Johan) <j.a.westerhuis@vu.nl>,
Wortel, M.T.M. (Meike) <m.t.wortel@vu.nl>, Wit, H.C. de (Renske) <h.c.de.wit@student.vu.nl><br>
<b>Subject: </b>FW: Seminar of Gunnar Klau (professor for Algorithmic Bioinformatics at Heinrich Heine University<o:p></o:p></span></p>
</div>
<p class="MsoNormal"><span lang="NL" style="font-size:11.0pt;mso-fareast-language:EN-US"> </span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">Dear colleagues,</span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:11.0pt"> <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">You are cordially invited to join the seminar of Gunnar Klau (professor for Algorithmic Bioinformatics at Heinrich Heine University, Düsseldorf, Germany)
on Tue. 12 December at 14.00-15.00 h in the O|2 auditorium. He will talk about his combinatorial approach to SARS-CoV-2 peptide vaccine design. See below for the full details of his talk, including abstract.</span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">We hope to see you all, and please feel free to share this invitation with other potentially interested colleagues.</span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:11.0pt"> <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">---</span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">Speaker: prof. dr. Gunnar Klau (Algorithmic Bioinformatics, Dept. Computer Science, HHU Düsseldorf, Germany)</span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">Date: Tue. 12 December, 14.00-15.00 h</span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">Location: Auditorium O|2 building</span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">Title: A combinatorial approach to SARS-CoV-2 peptide vaccine design</span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:11.0pt"> <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">Abstract:</span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:11.0pt"> <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">Peptide vaccines present a safe and cost-efficient alternative to traditional vaccines. Their efficacy depends on the peptides included in the vaccine and
the ability of major histocompatibility complex (MHC) molecules to bind and present these peptides. However, choosing a set of peptides that effectively achieve immunization across a large proportion of the population is challenging.</span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:11.0pt"> <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black">We present HOGVAX, a population-coverage-optimizing combinatorial approach to peptide vaccine design. Uniquely, HOGVAX exploits overlaps between peptides
to increase the number of peptides encoded in limited space, thereby enabling consideration of rare MHC alleles. We formalize the vaccine design task as a theoretical problem, which we call the Maximum Scoring k-Superstring Problem (MSKS). We show that MSKS
is NP-hard, and reformulate it into a graph problem using the hierarchical overlap graph (HOG). We give an integer linear programming formulation for the graph problem and provide an open source implementation.</span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black"> </span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="color:black"><img border="0" width="189" height="76" style="width:1.9687in;height:.7916in" id="Picture_x0020_9" src="cid:image001.png@01DA21FA.058D0700" alt="signature_1667789437"></span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black"> </span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Aptos",sans-serif;color:black"> </span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL" style="font-size:11.0pt;mso-fareast-language:EN-US"> </span><span lang="NL" style="font-size:11.0pt"><o:p></o:p></span></p>
</div>
</div>
</div>
</body>
</html>