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<p class="MsoNormal"><span lang="EN-US">Hello NMR users,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Some of you might have noticed that the integrals (belonging to a single compound) in
<u><sup>1</sup>H spectra recorded on the 500</u> do not show an optimal relation to another. In the
<sup>1</sup>H spectra the integrals in the higher frequency region (aromatic) are in general between 10-20% lower than in the lower frequency region. Though the spectra still look very good and can still be used to quite an extend for qualitative analyses,
it is a serious issue for quantitative experiments. <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Therefore, <u>do not use the 500 for quantitative analyses</u>. You can still use the 300 and, when authorized, the 600 for these types of experiments.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Sadly, this is a hardware issue that I cannot fix and Bruker has replaced the involved modules with no effect. I am working on a solution.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Please let me know if you have any questions.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Best,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Elwin<span style="color:black"><o:p></o:p></span></span></p>
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