<html><body><div style="font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000"><div><div><div><div id="zimbraEditorContainer" style="font-family: 'arial', 'helvetica', sans-serif; font-size: 12pt; color: #000000;" class="1" data-mce-style="font-family: 'arial', 'helvetica', sans-serif; font-size: 12pt; color: #000000;"><div><span style="font-size: 13pt;" data-mce-style="font-size: 13pt;"><strong><span lang="EN-US">Multiscale brain rhythms under healthy and epileptic conditions: </span><span lang="EN-GB">computational modeling insights for clinical applications</span></strong></span><span lang="EN-US"></span></div><div><p class="MsoNormal" align="left" style="text-align: left; margin: 0px;" data-mce-style="text-align: left; margin: 0px;"><span lang="EN-US"> </span></p><p class="MsoNormal" align="left" style="text-align: left; margin: 0px;" data-mce-style="text-align: left; margin: 0px;"><span lang="EN-US">Neural activity in the brain operates across multiple scales, encompassing both spatial and temporal dynamics. </span><span lang="EN-US" style="color: black;" data-mce-style="color: black;">In patients with epilepsy, however, cognitive impairments are often linked to disruptions in these neural mechanisms, particularly through interictal epileptiform discharges (IEDs).</span><span lang="EN-US"> </span><span lang="EN-US">This project aims to uncover new insights into the link between electrophysiology and attention deficits, one of the most prevalent cognitive impairments in patients with epilepsy, by exploring the role of IEDs. The PhD candidate will develop a comprehensive neocortical population model. The model will be validated on electrophysiological signals recorded in epileptic patients, and its dynamics will be studied to detail the mechanisms of multiple timescale interactions giving rise to healthy and pathological activity. </span></p><p class="MsoNormal" align="left" style="text-align: left; margin: 0px;" data-mce-style="text-align: left; margin: 0px;"><span lang="EN-US"> </span></p><p class="MsoNormal" align="left" style="text-align: left; margin: 0px;" data-mce-style="text-align: left; margin: 0px;"><span lang="EN-US">The research project is at the interface between </span><span lang="EN-GB" style="color: black;" data-mce-style="color: black;">computational, cognitive, and clinical neurosciences. </span><span lang="EN-US">The candidate will preferably have some background in applied mathematics or computational neuroscience/systems biology</span><span lang="EN-GB">. Programming skills in Python and knowledge of dynamical systems are required. </span><span lang="EN-US">Knowledge in cognitive neuroscience, electrophysiology and/or EEG analysis would be an asset. </span><span lang="EN-US"> </span><span lang="EN-US">The PhD fellow will join the </span><span lang="EN-GB"><span class="Object" role="link" id="OBJ_PREFIX_DWT265_com_zimbra_url"><a href="https://cophyteam.fr/" target="_blank" rel="nofollow noopener noreferrer" data-mce-href="https://cophyteam.fr/"><span lang="EN-US">Cophy Team</span></a></span></span><span lang="EN-US"> hosted at the </span><span class="mt-3"><span lang="EN-GB">Center for Neuroscience Research of Lyon (CRNL), France</span></span><span lang="EN-US">. </span><span lang="EN-GB">The ideal start date is September 2025, with some flexibility.</span><span lang="EN-US"></span></p><p class="MsoNormal" style="margin: 0px;" data-mce-style="margin: 0px;"><span lang="EN-US"> </span></p><p class="MsoNormal" style="margin: 0px;" data-mce-style="margin: 0px;"><span lang="EN-US">Candidates should send their CV, </span><span lang="EN-GB">a motivation letter, contact information for 2-3 references and</span><span lang="EN-GB"> </span><span lang="EN-US">their master degree notes (if available) to Elif Köksal-Ersöz </span><span lang="EN-GB"><span class="Object" role="link" id="OBJ_PREFIX_DWT266_ZmEmailObjectHandler"><a href="mailto:elif.koksal@inria.fr" target="_blank" rel="nofollow noopener noreferrer" data-mce-href="mailto:elif.koksal@inria.fr"><span lang="EN-US">elif.koksal@inria.fr</span></a></span></span><span lang="EN-GB"> and </span><span lang="EN-US">Mathilde Bonnefond </span><span lang="EN-GB"><span class="Object" role="link" id="OBJ_PREFIX_DWT267_ZmEmailObjectHandler"><a href="mailto:mathilde.bonnefond@inserm.fr" target="_blank" rel="nofollow noopener noreferrer" data-mce-href="mailto:mathilde.bonnefond@inserm.fr"><span lang="EN-US">mathilde.bonnefond@inserm.fr</span></a></span></span><span lang="EN-US"> until <strong>June 10<sup>th</sup> 2025</strong>. </span></p><p class="MsoNormal" align="left" style="text-align: left; margin: 0px;" data-mce-style="text-align: left; margin: 0px;"><span lang="EN-US"> </span></p><p class="MsoNormal" align="left" style="text-align: left; margin: 0px;" data-mce-style="text-align: left; margin: 0px;"><span lang="EN-US">Related Publications:</span></p><ol style="margin-top: 0cm;" start="1" type="1" data-mce-style="margin-top: 0cm;"><li class="MsoNormal"><span lang="EN-US">Bonnefond M</span><span lang="EN-US">, Kastner S, Jensen O. Communication between Brain Areas Based on Nested Oscillations. eNeuro. 2017; 4(2). </span></li><li class="MsoNormal"><span lang="EN-US">Köksal-Ersöz E</span><span lang="EN-US">, Lazazzera R, Yochum M, Merlet I, Makhalova J, Mercadal B, et al. Signal processing and computational modeling for interpretation of SEEG-recorded interictal epileptiform discharges in epileptogenic and non-epileptogenic zones. J Neural Eng. 2022;19(5):055005.</span></li><li class="MsoNormal" style="text-align: left;" data-mce-style="text-align: left;"><span lang="EN-GB">Köksal-Ersöz E</span><span lang="EN-GB">, Yochum M, Benquet P, Wendling F. eCOALIA: Neocorticalneural mass model for simulating electroencephalographic signal, SoftwareX. 2024, 28: 101924.</span><span lang="EN-US"></span></li><li class="MsoNormal" style="text-align: left;" data-mce-style="text-align: left;"><span lang="FR">Thieux M, </span><span lang="FR">Jung J.</span><span lang="FR"> <i>et al.</i> BLAST paradigm. </span><span lang="EN-US">Epilepsy & Behavior. 2019<i>;</i> 99: 106470.</span></li></ol></div></div></div></div></div><div><br></div><div data-marker="__SIG_PRE__"><div><table style="height:298px;width:262px;float:left" cellpadding="2" border="0" cellspacing="1"><tbody><tr style="height:91px"><td style="width:262px;height:91px"><div><strong><span style="font-size:10pt">Elif Köksal-Ersöz</span></strong><br><br><span style="font-size:10pt">Scientific researcher</span><br></div><div><span style="font-size:10pt"><a href="https://elifkoksal.github.io/" rel="nofollow noopener noreferrer nofollow noopener noreferrer nofollow noopener noreferrer" target="_blank">https://elifkoksal.github.io/</a></span><br></div><br></td></tr><tr style="height:109px"><td style="width:262px;height:109px"><div><span style="font-size:10pt">Centre Inria de Lyon & CRNL</span><br><span style="font-size:10pt">CH Le Vinatier Bâtiment 452</span><br><span style="font-size:10pt">95 boulevard Pinel</span><br><span style="font-size:10pt">69500 Bron, France</span></div><div><br></div><div><a href="https://www.inria.fr/en" target="_blank" rel="nofollow noopener noreferrer"><strong><span style="font-size:10pt;color:rgb( 255 , 0 , 0 )">www.inria.fr</span></strong></a><br></div></td></tr><tr style="height:18px"><td style="width:262px;height:18px"><br></td></tr><tr style="height:80px"><td style="width:262px;height:80px"><img src="cid:c1c614ab4149e67d666e1eb296da5c3ae333768c@zimbra"></td></tr></tbody></table></div><div><br></div><div><br></div><div><br></div><div><a href="https://elifkoksal.github.io/" rel="nofollow noopener noreferrer nofollow noopener noreferrer nofollow noopener noreferrer" target="_blank"></a><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br><br><br></div></div></div></body></html>